Clade canvasses three generations from the very near future to late this century. Central to the novel is the family of Adam, a scientist, and his wife Ellie, an artist. Clade opens with them wanting a child and Adam in a quandary about the wisdom of this. Their daughter proves to be an elusive little girl and then a troubled teenager, and by now cracks have appeared in her parents' marriage. Their grandson is in turn a troubled boy, but when his character reappears as an adult he's an astronomer, one set to discover something astounding in the universe.